Presentation
Hi there! I am a biophysicist and entrepreneur based in Paris. With my friends Diane-Laure and Fanny we’re building the platform that will enable researchers and clinicians to treat cancer as a rare disease, at scale. We do this thanks to the combined power of automation, AI and, most importantly, patient-derived organoids. These small clumps of patient cells reproduce key features of the tumour they come from and by analyzing their responses to drugs we can gain insights on how patients would have reacted. Logically, we decided to call this venture Orakl because we can see the future (sort of).
Until recently, I used to work in the Physical Microfluidics and Bioengineering lab at the Pasteur Institute. The PμB develops new microfluidic setups and quantitative tools to study complex biological phenomena, such as yeast DNA repair mechanisms or the bacterial SOS response.
I have recently completed my PhD between the Pasteur Institute and the École polytechnique. My PhD project involved investigating cell-cell interactions in complex biological systems. In particular, I studied immune-tumor cell interactions in microfluidic chips. With advanced imaging pipelines and coupled with some additional mathematical modeling, I showed how immune cells accumulate at tumor sites and how they successfully - or not - kill cancer cells.
Publications & Conferences
Research publications
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Ronteix, Gustave; Josserand, Christophe; Adélaide Lety-Stefanka; Baroud, Charles; Amselem, Gabriel, Rheotaxis of chiral bacteria: from single-cell behavior to a population-level description, Under Review (2022)
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Ronteix, Gustave; Bonnet, Valentin; Sart, Sébastien; Esposito, Elric; Baroud, Charles, Griottes: a generalist tool for network generation from segmented tissue images, BMC Biology (2022)
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Ronteix, Gustave; Jain, Shreyansh; Angely, Christelle; Cazaux, Marine; Khazen, Roxana; Bousso, Philippe; Baroud, Charles, A Multiscale Immuno-Oncology on-Chip System (MIOCS) establishes that collective T cell behaviors govern tumor regression, Nature Communications (2022)
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Sart, Sebastien; Ronteix, Gustave; Jain, Shreyansh; Amselem, Gabriel; Baroud, Charles, Cell culture in microfluidic droplets, Chemical Reviews (2022)
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Margot Bardou, Jérémy Postat, Clémence Loaec, Fabrice Lemaître, Gustave Ronteix, Zacarias Garcia, Philippe Bousso, Quorum sensing governs collective dendritic cell activation in vivo., The EMBO Journal (2021)
Conference talks
- 10/2021: “Network-based approaches for the structural analysis of the fetal liver”, Institut Pasteur Genomes and Genetics department day.
- 04/2021: “Multiscale analysis of the initiation of the immune response reveals that collective T cell behaviours govern tumour regression”, Institut Pasteur Translational Day 2021, Cancer & Immunotherapy
- 04/2021: “Collective T cell behaviours govern tumour regression on chip”, EMBO Virtual Workshop on ImmunoBiophysics
- 10/2020: “Quantitative analysis of Self- Organisation in 3D Mesenchymal Bodies”, Institut Pasteur BCI department day.
- 07/2020: “Spheroid tumor models for the quantitative analysis of immune-cancer interactions”, EMBL Conference Microfluidics: Designing the Next Wave of Biological Inquiry
Poster presentations
- 11/2019: “Quantitative analysis of spheroid tumor models for immuno-oncology”, Journées de l’École Doctorale Paris-Saclay
- 10/2019: “Spheroid tumor models for the quantitative analysis of immune-cancer interactions”, Institut Pasteur Genomes & Genetics department days.
- 06/2019: “Spheroid tumor models for the quantitative analysis of immune-cancer interactions”, GRC Conference:Physics and Chemistry of Microfluidics
Other
From time to time, I write for the European journal Le Grand Continent, you can find most of my articles here. I also share some of my more informal thoughts on my newsletter. Feel free to subscribe if you’re into reading my mumblings!
Contact
Education
| Year | Diploma |
|---|---|
| 2021 | PhD student in Biophysics, Institut Pasteur, France |
| 2018 | MPhil in Engineering, University of Cambridge, UK |
| 2018 | Master in Physics, École polytechnique, France |
| 2015 | Bachelor in Physics, École polytechnique, France |
References
- Dr. Charles Baroud: Professor, École polytechnique
- Dr. Thierry Savin: Associate Professor, Cambridge University